Unoprostone Isopropyl and Metabolite M1 Activate BK Channels and Prevent ET-1–Induced [Ca2]i Increases in Human Trabecular Meshwork and Smooth Muscle
نویسندگان
چکیده
PURPOSE. Effects of cis-unoprostone isopropyl, its primary metabolite M1, trans-unoprostone isopropyl, latanoprost free acid, and fluprostenol were studied on Ca2þ-activated Kþ (BK) channels, plasma membrane potential, [cAMP]i, [cGMP]i, and steady state [Ca]i, and protection against endothelin-1 (ET-1)– induced steady state [Ca]i increases in human cortical neuronal (HCN-1A), trabecular meshwork (HTMC), and pulmonary artery smooth muscle (PASMC) cells. Effects on recombinant human prostaglandin (PG) receptors were determined.
منابع مشابه
Unoprostone isopropyl and metabolite M1 activate BK channels and prevent ET-1-induced [Ca²⁺]i increases in human trabecular meshwork and smooth muscle.
PURPOSE Effects of cis-unoprostone isopropyl, its primary metabolite M1, trans-unoprostone isopropyl, latanoprost free acid, and fluprostenol were studied on Ca(2+)-activated K(+) (BK) channels, plasma membrane potential, [cAMP](i), [cGMP](i), and steady state [Ca(2+)](i), and protection against endothelin-1 (ET-1)-induced steady state [Ca(2+)](i) increases in human cortical neuronal (HCN-1A), ...
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